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1

Potential Molecular Targeted Therapeutics: Role of PI3-K/Akt/mTOR Inhibition in Cancer

M. Sokolowski, Kevin, Koprowski, Steven, Kunnimalaiyaan, Selvi, Balamurugan, Mariappan, Clark Gamblin, T., Kunnimalaiyaan, Muthusamy

Journal:

Anti-Cancer Agents in Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 924 KB

english, 2015

2

Required sequence elements for chloroplast DNA replication activity in vitro and in electroporated chloroplasts

Samantha K. Lugo, Muthusamy Kunnimalaiyaan, Narendra K. Singh, Brent L. Nielsen

Journal:

Year:

2004

Language:

english

File:

PDF, 448 KB

english, 2004

3

Xanthohumol Inhibits Notch Signaling and Induces Apoptosis in Hepatocellular Carcinoma

Kunnimalaiyaan, Selvi, Sokolowski, Kevin M., Balamurugan, Mariappan, Gamblin, T. Clark, Kunnimalaiyaan, Muthusamy, Calvisi, Diego

Journal:

Year:

2015

Language:

english

File:

PDF, 2.67 MB

english, 2015

4

Antiproliferative Effect Of Chrysin On Anaplastic Thyroid Cancer

T.X. Phan, X. Yu, M. Kunnimalaiyaan, H. Chen

Journal:

Journal of Surgical Research

Year:

2011

Language:

english

File:

PDF, 248 KB

english, 2011

5

Antiproliferative Effect Of Chrysin On Anaplastic Thyroid Cancer

T.X. Phan, X. Yu, M. Kunnimalaiyaan, H. Chen

Journal:

Journal of Surgical Research

Year:

2011

Language:

english

File:

PDF, 76 KB

english, 2011

6

ZM336372, A Raf-1 Activator, Causes Suppression of Proliferation in a Human Hepatocellular Carcinoma Cell Line

Dustin Deming, Peter Geiger, Herbert Chen, Abram Vaccaro, Muthusamy Kunnimalaiyaan, Kyle Holen

Journal:

Journal of Gastrointestinal Surgery

Year:

2008

Language:

english

File:

PDF, 196 KB

english, 2008

7

Suberoyl Bishydroxamic Acid Activates Notch1 Signaling and Suppresses Tumor Progression in an Animal Model of Medullary Thyroid Carcinoma

Li Ning, Renata Jaskula-Sztul, Muthusamy Kunnimalaiyaan, Herbert Chen

Journal:

Annals of Surgical Oncology

Year:

2008

Language:

english

File:

PDF, 271 KB

english, 2008

8

Histone deacetylase inhibitors upregulate Notch-1 and inhibit growth in pheochromocytoma cells

Joel T. Adler, Daniel G. Hottinger, Muthusamy Kunnimalaiyaan, Herbert Chen

Journal:

Year:

2008

Language:

english

File:

PDF, 394 KB

english, 2008

9

Neuroendocrine tumor cell growth inhibition by ZM336372 through alterations in multiple signaling pathways

Muthusamy Kunnimalaiyaan, Mary Ndiaye, Herbert Chen

Journal:

Year:

2007

Language:

english

File:

PDF, 288 KB

english, 2007

10

101: In vitro and in vivo carcinoid cell growth inhibition by glycogen synthase kinase-3β

M. Kunnimalaiyaan, D.Y. Greenblatt, M. Ndiaye, H. Chen

Journal:

Journal of Surgical Research

Year:

2007

Language:

english

File:

PDF, 150 KB

english, 2007

11

PL13. Identification and Validation of the Novel Notch1 Activator, Resveratrol, via a Quantitative High-Throughput Assay

S.N. Pinchot, R. Jaskula-Sztul, L. Ning, M. Kunnimalaiyaan, H. Chen

Journal:

Journal of Surgical Research

Year:

2009

Language:

english

File:

PDF, 423 KB

english, 2009

12

QS275. AKT and PTEN Expression in Human Carcinoid Tumors

S.C. Pitt, R. Davis, M. Kunnimalaiyaan, H. Chen

Journal:

Journal of Surgical Research

Year:

2009

Language:

english

File:

PDF, 67 KB

english, 2009

13

The role of human achaete-scute homolog-1 in medullary thyroid cancer cells

Rebecca S Sippel, Jennifer E Carpenter, Muthusamy Kunnimalaiyaan, Herbert Chen

Journal:

Year:

2003

Language:

english

File:

PDF, 394 KB

english, 2003

14

Synergistic Effect of Pasireotide and Teriflunomide in Carcinoids in vitro

Somnay, Yash, Chen, Herbert, Kunnimalaiyaan, Muthusamy

Journal:

Neuroendocrinology

Year:

2013

Language:

english

File:

PDF, 1.54 MB

english, 2013

15

Valproic Acid Activates Notch1 Signaling and Induces Apoptosis in Medullary Thyroid Cancer Cells

Greenblatt, David Yu, Cayo, Max A., Adler, Joel T., Ning, Li, Haymart, Megan R., Kunnimalaiyaan, Muthusamy, Chen, Herbert

Journal:

Annals of Surgery

Year:

2008

Language:

english

File:

PDF, 436 KB

english, 2008

16

Action of YM155 on clear cell renal cell carcinoma does not depend on survivin expression levels

Sim, Mei Yi, Huynh, Hung, Go, Mei Lin, Yuen, John Shyi Peng, Kunnimalaiyaan, Muthusamy

Journal:

Year:

2017

Language:

english

File:

PDF, 7.13 MB

english, 2017

17

Characterization of replication origins flanking the 23S rRNA gene in tobacco chloroplast DNA

Zhun Lu, Muthusamy Kunnimalaiyaan, Brent L. Nielsen

Journal:

Plant Molecular Biology

Year:

1996

Language:

english

File:

PDF, 1.90 MB

english, 1996

18

A mouse model of carcinoid syndrome and heart disease

Sandeepa Musunuru, Rebecca Sippel, Muthusamy Kunnimalaiyaan, Herbert Chen

Journal:

Journal of the American College of Surgeons

Year:

2004

Language:

english

File:

PDF, 51 KB

english, 2004

19

Lithium ions: A novel treatment for pheochromocytomas and paragangliomas

Ashley Kappes, Abram Vaccaro, Muthusamy Kunnimalaiyaan, Herbert Chen

Journal:

Year:

2007

Language:

english

File:

PDF, 198 KB

english, 2007

20

P70: Notch1 signaling mediated growth arrest in prostate cancer cells by valproic acid

M.M. Boockmeier, M. Ndiaye, M. Kunnimalaiyaan, H. Chen

Journal:

Journal of Surgical Research

Year:

2007

Language:

english

File:

PDF, 42 KB

english, 2007

21

Chloroplast DNA Replication : Mechanism, Enzymes and Replication Origins

Muthusamy Kunnimalaiyaan, Brent L. Nielsen

Journal:

Journal of Plant Biochemistry and Biotechnology

Year:

1997

Language:

english

File:

PDF, 831 KB

english, 1997

22

Molecular Characterization of Plasmid pBM300 from Bacillus megaterium QM B1551

Kunnimalaiyaan, M., Vary, P. S.

Journal:

Applied and Environmental Microbiology

Year:

2005

Language:

english

File:

PDF, 547 KB

english, 2005

23

Resveratrol Induces Differentiation Markers Expression in Anaplastic Thyroid Carcinoma via Activation of Notch1 Signaling and Suppresses Cell Growth

Yu, X.-M., Jaskula-Sztul, R., Ahmed, K., Harrison, A. D., Kunnimalaiyaan, M., Chen, H.

Journal:

Molecular Cancer Therapeutics

Year:

2013

Language:

english

File:

PDF, 1.34 MB

english, 2013

24

MicroRNA profiling of benign and malignant pheochromocytomas identifies novel diagnostic and therapeutic targets

Meyer-Rochow, G. Y., Jackson, N. E., Conaglen, J. V., Whittle, D. E., Kunnimalaiyaan, M., Chen, H., Westin, G., Sandgren, J., Stalberg, P., Khanafshar, E., Shibru, D., Duh, Q.-Y., Clark, O. H., Kebebe

Journal:

Endocrine Related Cancer

Year:

2010

Language:

english

File:

PDF, 306 KB

english, 2010

25

Identification and validation of Notch pathway activating compounds through a novel high-throughput screening method

Scott N. Pinchot, Renata Jaskula-Sztul, Li Ning, Noel R. Peters, Mackenzie R. Cook, Muthusamy Kunnimalaiyaan, Herbert Chen

Journal:

Year:

2011

Language:

english

File:

PDF, 527 KB

english, 2011

26

Targeting Notch As A Therapy For Hepatocellular Carcinoma

Kunnimalaiyaan, M., Kunnimalaiyaan, S., Gamblin, T.

Journal:

Journal of Surgical Research

Year:

2014

Language:

english

File:

PDF, 60 KB

english, 2014

27

Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3

Adler, J. T., Cook, M., Luo, Y., Pitt, S. C., Ju, J., Li, W., Shen, B., Kunnimalaiyaan, M., Chen, H.

Journal:

Molecular Cancer Therapeutics

Year:

2009

Language:

english

File:

PDF, 479 KB

english, 2009

28

Integration ofhupcosmid pHU52 into the chromosomal DNA ofCicer-Rhizobiumusing Tn5 as an homologous sequence

M. Kunnimalaiyaan, M. L. Lodha, K. R. Sreekumar

Journal:

World Journal of Microbiology and Biotechnology

Year:

1992

Language:

english

File:

PDF, 872 KB

english, 1992

29

PI3K-Akt signaling in pulmonary carcinoid cells

Susan C. Pitt, Herbert Chen, Muthusamy Kunnimalaiyaan

Journal:

Journal of the American College of Surgeons

Year:

2008

Language:

english

File:

PDF, 48 KB

english, 2008

30

A Mouse Model of Carcinoid Syndrome and Heart Disease

Sandeepa Musunuru, Jennifer E. Carpenter, Rebecca S. Sippel, Muthusamy Kunnimalaiyaan, Herbert Chen

Journal:

Journal of Surgical Research

Year:

2005

Language:

english

File:

PDF, 209 KB

english, 2005

31

Resveratrol Induces Apoptosis and Suppresses Neuroedocrine Markers in Medullary Thryoid Cancer

M. Truong, M.R. Cook, S.N. Pinchot, M. Kunnimalaiyaan, H. Chen

Journal:

Journal of Surgical Research

Year:

2010

Language:

english

File:

PDF, 42 KB

english, 2010

32

QS303. ZM336372 Suppresses Growth in Ovarian Cancer Cell Lines by Phosphorylation of GSK-3β

N.L. Seiler, M. Kunnimalaiyaan, L. Krichevsky, S.L. Rose

Journal:

Journal of Surgical Research

Year:

2009

Language:

english

File:

PDF, 72 KB

english, 2009

33

Suberoyl Bis-Hydroxamic Acid Activates Notch-1 Signaling and Induces Apoptosis in Medullary Thyroid Carcinoma Cells

Ning, L., Greenblatt, D. Y., Kunnimalaiyaan, M., Chen, H.

Journal:

Year:

2008

Language:

english

File:

PDF, 267 KB

english, 2008

34

Suberoyl Bishydroxamic Acid Inhibits Cellular Proliferation by Inducing Cell Cycle Arrest in Carcinoid Cancer Cells

David Yu Greenblatt, Max Cayo, Li Ning, Renata Jaskula-Sztul, Megan Haymart, Muthusamy Kunnimalaiyaan, Herbert Chen

Journal:

Journal of Gastrointestinal Surgery

Year:

2007

Language:

english

File:

PDF, 216 KB

english, 2007

35

Analysis of the tobacco chloroplast DNA replication origin (ori B) downstream of the 23 S rRNA gene

Muthusamy Kunnimalaiyaan, Fengjie Shi, Brent L Nielsen

Journal:

Journal of Molecular Biology

Year:

1997

Language:

english

File:

PDF, 407 KB

english, 1997

36

In vivo activation of raf-1 inhibits tumor growth and development in a xenograft model of human MTC

A.M. Vaccaro, H. Chen, M. Kunnimalaiyaan

Journal:

Journal of Surgical Research

Year:

2006

Language:

english

File:

PDF, 86 KB

english, 2006

37

QS128. Inhibition of Growth in Medullary Thyroid Cancer Cells With Histone Deacetylase Inhibitors and Lithium Chloride

J.T. Adler, D.G. Hottinger, M. Kunnimalaiyaan, H. Chen

Journal:

Journal of Surgical Research

Year:

2009

Language:

english

File:

PDF, 68 KB

english, 2009

38

Conservation of the notch1 signaling pathway in gastrointestinal (GI) neuroendocrine (NE) tumor cells

M. Kunnimalaiyaan, K. Traeger, J.E. Carpenter, R.S. Sippel, H. Chen

Journal:

Journal of Surgical Research

Year:

2003

Language:

english

File:

PDF, 48 KB

english, 2003

39

Chrysin induces growth suppression through apoptosis in neuroblastoma cells

Jocelyn F. Burke, Logan Schlosser, Herbert Chen, Muthusamy Kunnimalaiyaan

Journal:

Journal of the American College of Surgeons

Year:

2012

Language:

english

File:

PDF, 60 KB

english, 2012

40

MK-2206 Causes Growth Suppression and Reduces Neuroendocrine Tumor Marker Production in Medullary Thyroid Cancer Through Akt Inhibition

Jocelyn F. Burke MD, Logan Schlosser BS, April D. Harrison BS, Muthusamy Kunnimalaiyaan PhD, Herbert Chen MD, FACS

Journal:

Annals of Surgical Oncology

Year:

2013

Language:

english

File:

PDF, 369 KB

english, 2013

41

Expression of Chromosome-integrated Hydrogen-uptake Genes inCicer-Rhizobium

M. Kunnimalaiyaan,M. L. Lodha

Journal:

Journal of Plant Biochemistry and Biotechnology

Year:

1992

Language:

english

File:

PDF, 510 KB

english, 1992

42

Combination Therapy with Histone Deacetylase Inhibitors and Lithium Chloride: A Novel Treatment for Carcinoid Tumors

Joel T. Adler, Daniel G. Hottinger, Muthusamy Kunnimalaiyaan, Herbert Chen

Journal:

Annals of Surgical Oncology

Year:

2009

Language:

english

File:

PDF, 335 KB

english, 2009

43

Characterization of a Theta Plasmid Replicon with Homology to All Four Large Plasmids ofBacillus megateriumQM B1551

David M. Stevenson, Muthusamy Kunnimalaiyaan, Kerstin Müller, Patricia S. Vary

Journal:

Year:

1998

Language:

english

File:

PDF, 406 KB

english, 1998

44

In vitro replication of mitochondrial plasmid mp1 from the higher plant Chenopodium album (L.): a remnant of bacterial rolling circle and conjugative plasmids?

Steffen Backert, Muthusamy Kunnimalaiyaan, Thomas Börner, Brent L Nielsen

Journal:

Journal of Molecular Biology

Year:

1998

Language:

english

File:

PDF, 562 KB

english, 1998

45

Multifunctional Gold Nanorods for Targeted Drug Delivery To Carcinoids

R. Jaskula-Sztul, Y. Xiao, A. Javadi, J. Eide, W. Xu, M. Kunnimalaiyaan, S. Gong, H. Chen

Journal:

Journal of Surgical Research

Year:

2012

Language:

english

File:

PDF, 131 KB

english, 2012

46

The Synergistic Effect of Pasireotide and a Raf-1 Activating Agent in Carcinoids

Y.R. Somnay, H. Chen, M. Kunnimalaiyaan

Journal:

Journal of Surgical Research

Year:

2011

Language:

english

File:

PDF, 156 KB

english, 2011

47

Co-delivery of doxorubicin and siRNA using octreotide-conjugated gold nanorods for targeted neuroendocrine cancer therapy

Xiao, Yuling, Jaskula-Sztul, Renata, Javadi, Alireza, Xu, Wenjin, Eide, Jacob, Dammalapati, Ajitha, Kunnimalaiyaan, Muthusamy, Chen, Herbert, Gong, Shaoqin

Journal:

Year:

2012

Language:

english

File:

PDF, 646 KB

english, 2012

48

MK2206 inhibits hepatocellular carcinoma cellular proliferation via induction of apoptosis and cell cycle arrest

Wilson, J.M., Kunnimalaiyaan, S., Gamblin, T.C., Kunnimalaiyaan, M.

Journal:

Journal of Surgical Research

Year:

2014

Language:

english

File:

PDF, 339 KB

english, 2014

49

Structure-Based Functional Analysis of the Replication Protein of Plasmid R6K: Key Amino Acids at the /DNA Interface

Kunnimalaiyaan, S., Rakowski, S. A., Filutowicz, M.

Journal:

Journal of Bacteriology

Year:

2007

Language:

english

File:

PDF, 235 KB

english, 2007

50

The Natural Flavinoid, Chrysin, in the Treatment of Medullary Thyroid Cancer

B. Zarebczan, M. Kunnimalaiyaan, H. Chen

Journal:

Journal of Surgical Research

Year:

2012

Language:

english

File:

PDF, 54 KB

english, 2012

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